Androgen insensitivity syndrome (AIS) is caused by a genetic fault that means the body can’t respond to testosterone properly. The faulty gene is usually passed on to a child by their mother. Testosterone is the male sex hormone produced by the testicles.Click to see full answer. Similarly, it is asked, what is the cause of androgen insensitivity syndrome?Mutations in the AR gene cause androgen insensitivity syndrome. This gene provides instructions for making a protein called an androgen receptor. Androgen receptors allow cells to respond to androgens, which are hormones (such as testosterone) that direct male sexual development.Also Know, how is AIS inherited? Because AIS is a genetic defect located on the X chromosome, it runs in families. Except for spontaneous mutations, the mother of an AIS individual is a carrier, and her XY children have a 1/2 chance of having AIS. Her XX children have a 1/2 chance of carrying the AIS gene. Considering this, what are the symptoms of androgen insensitivity syndrome? Signs and symptoms Infants with complete androgen insensitivity syndrome appear to be female at birth, but do not have a uterus, fallopian tubes or ovaries. Their testicles are hidden inside the pelvis or abdomen. Breasts develop during puberty, but there is little or no pubic and armpit hair.What is androgen insensitivity syndrome?Androgen insensitivity syndrome (AIS) is when a person who is genetically male (who has one X and one Y chromosome) is resistant to male hormones (called androgens). As a result, the person has some or all of the physical traits of a woman, but the genetic makeup of a man.
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